Multiple Skins Question
Using Jamroom
The Admin Skin module will let you have different skins for main pages, profiles and the ACP, but to how a skin specified just for the homepage is not doable out of the box.
Nothing is impossible though. Is it an alternative layout you want, or colour scheme, or both? If both, you could grab the template code from the desired homepage skin and paste it into the existing homepage template, and then you would need to copy/edit the css just for the homepage. It could get a bit messy and complex doing it, but its possible.
hth