Eliminating the spacing between each ARTISTS image / details when adding more info like biography
Design and Skin Customization
I think what you are describing is a grid, where the heights of each box are not equal which is causing you a layout problem? If you posted a link with your question it would be much easier for you to describe, and easier for everyone else.
3 possible solutions:
Pinterest will be using something like Masonry to create it's grid - a javascript plugin to lay things out with no gaps. There are others but this is the best one I know of:
http://masonry.desandro.com/
If you need to keep things in rows you could also look at some jquery to give you equal height boxes within each row (the empty space is within the box rather than below it). Again, there are many, I use this one:
https://github.com/filamentgroup/jQuery-Equal-Heights
You could also use css to fill vertically by columns rather than rows. But I haven't tried that, and you should check browser support for it.
https://developer.mozilla.org/en-US/docs/Web/Guide/CSS/Using_multi-column_layouts
updated by @ultrajam: 08/19/14 03:22:54PM