New Module - Single Front Page Presentation for Profiles
Suggestions
Skin Config options are all dependent on the skin, and affect mostly areas OUTSIDE the profile, so the profile tweaks module will not work with the skin config settings. It also needs to work with ALL skins, regardless of their HTML structure.
If you need more than that, you'll want to look at creating some custom SKINS that you can then let your profiles select as part of the profile tweaks module.